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Abstract

FTIR Spectrometric Determination Of Sulphamethoxazole And Trimethoprim In Co-Trimoxazole Tablets

Author(s): S. H Ahmadi, K Kargosha, R Bahadori

A method has been developed for the determination of sulphamethoxazole (SMX) and trimethoprim (TMP) in pharmaceuticals by fourier transform infrared (FTIR) spectrometry. The method is based on the fractional dissolving of SMX and TMP in acetone and chloroform respectively. SMX is then determined by absorbance measurements at 1165 cm-1 and TMP by using the absorbance values at 1126 cm-1, separately. The method provides precise and accurate results for the analysis of real samples of the binary dosage form of SMX and TMP, co-trimoxazole.

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