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Gas Chromatography-Mass Spectrometric Analysis, Isolation, Characterization and Biological Activity of Ethanolic Extract of Moss Fabronia secunda Mont.

Author(s): K. N. Killari, D. S. N. B. K. Prasanth, P. K. Pasala, Ho Viet Hieu, Alekhya Ketha, V. B. Tatipamula* and K. Prasad
Department of Pharmacology, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh 534201, 1Department of Pharmacognosy, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh 520010, 2Department of Pharmacology, Santhiram College of Pharmacy, Nandyal, Andhra Pradesh 518112, India, 3Department of Medical Microbiology and Parasitology, Duy Tan University, Da Nang 550000, Vietnam, 4Department of Pharmaceutical Chemistry, Bharat Institute of Technology-Pharmacy, Mangalpally, Telangana 501510, India, 5Center for Molecular Biology, College of Medicine and Pharmacy, Duy Tan University, Danang 550000, Vietnam

Correspondence Address:
V. B. Tatipamula, Center for Molecular Biology, College of Medicine and Pharmacy, Duy Tan University, Danang 550000, Vietnam, E-mail:

The chemical and biological profile of the ethanolic extract of Fabronia secunda examined for the first time. The gas chromatography-mass spectrometric analysis of ethanolic extract of Fabronia secunda identified 200 components, which mainly composed of lup-20(29)-ene-3,28-diol (4.01 %), guanosine (3.99 %), and 1,2-benzene-dicarboxylic acid (3.79 %). Also, the chromatographic analysis yielded three compounds, namely stigmasterol (1), β-sitosterol (2) and lupeol (3). The ethanolic extract of Fabronia secunda exhibited superior inhibition of superoxide and 2,2-diphenyl-1-picrylhydrazyl radicals with an half maximal inhibitory concentration value of 33.5 and 34.5 μg/ml respectively. Additionally, ethanolic extract of Fabronia secunda depicted prominent inhibitory profiles against alpha-glucosidase and pancreatic alpha-amylase with half maximal inhibitory concentration values of 48.5 and 58.0 μg/ml respectively. To conclude, this preliminary chemical analysis provides a piece of evidence to know the metabolism of mosses and the biological investigation proved the therapeutic importance of mosses like Fabronia secunda.

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