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Abstract

Gene Therapy In Hypertension

Author(s): Rajeshri G Karki, Anita A Mehta, R. K Goyal

Gene therapy is emerging out as an important trend in the pathophysiology and treatment of hypertension. Several gene targets have been identified in recent years. They include rennin, angiotensin converting enzyme, anglotensin receptors, kallikrein, endothelin, nitric oxide, adrenomedullin, glucocorticoid- suppressible hyperaldosteronism and several peptides including atrial natriuretic factor. Clinically, there are several problems before gene therapy is actually available. Once gene therapy becomes a reality, it will be a significant break through in the field of treatment of hypertension.

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