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Hepatoprotective activity of Ficus carica leaf extract on rifampicin-induced hepatic damage in rats

Author(s): NY Gond1, SS Khadabadi2
1Department of Pharmacognosy, Nanded Pharmacy College, Nanded-431 605, India 2Government College of Pharmacy, Amravati-444 603, India

Correspondence Address:
N Y Gond Department of Pharmacognosy, Nanded Pharmacy College, Nanded-431 605 India E-mail: [email protected]

Shade dried leaves of Ficus carica were extracted using petroleum ether (60-80°) and tested for antihepatotoxic activity on rats treated with 50 mg/kg of rifampicin orally. The parameters assessed were serum levels of glutamic oxaloacetate transaminase, glutamic pyruvic transaminase, bilirubin and histological changes in liver. Liver weights and pentobarbitione sleeping time as a functional parameter were also monitored. There was significant reversal of biochemical, histological and functional changes induced by rifampicin treatment in rats by petroleum ether extract treatment, indicating promising hepatoprotective activity.

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