All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Hepatoprotective Activity Of Polygala Elongata Against CCI4-Induced Hepatotoxicity In Rats

Author(s): Annie Shirwaikar, R Padma, A Vasanth Kumar, Lakshmi Rao

The ethanolic extract of the plant Polygala elongata Klein Ex. Willd (Polygalaceae) was lnvesti- gated for its hepatoprotective activity in male Wistar rats. In acute toxicity studies, the extract when administered to mice as a single I.p. dose of 1000 mg/kg was found to be non toxic. The extract exhibited significant hepatoprotective activity at 200 mg/kg body weight, which was comparable to the activity exhibited by the reference standard, silymarln in carbon tetrachloride-induced hepatoxicity model. Mangiferin, a xanthone, was the main component isolated from the ethyl methyl ketone fraction of the ethanolic extract. The flavonoid, quercetin-3-O-β-D glucoside was also isolated from the ethyl acetate fraction.

PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report