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Abstract

High performance liquid chromatographic determination of oxymetazoline hydrochloride from nasal drops.

Author(s): RT Sane, LS Joshi, KD Ladage, RM Kothurkar, VR Bhate
S.P. Mandali's TDM Laboratory, Plot No. 194, Scheme 6, Road No.15,Sion-Koliwada, Sion (East), Bombay-400 022,

Correspondence Address:
R T Sane S.P. Mandali's TDM Laboratory, Plot No. 194, Scheme 6, Road No.15,Sion-Koliwada, Sion (East), Bombay-400 022

A reversed-phase HPLC assay procedure for the determination of oxymetazoline hydrochloride and its dosage forms is described. The compound was chromatographed on a C18 column using a mobile phase consisting of methanol: acentonitrile: water : diethylamine (45:20:35:0.3). The low values of standard deviation and coefficient of variation indicate good precision of the proposed method. The percentage recovery being 100 +/- 2 percent indicates non-interference from other excipients present in the formulations. PDF

 
 
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