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Abstract

High Performance Liquid Chromatographic Estimation Of Ciprofloxacin Hydrochloride And Tinidazole From Tablets

Author(s): M. S Bhatia, S. G Kaskhedikar, S. C Chaturvedi

A new precise, selective and accurate reverse phase high performance liquid chromatographic method for simultaneous estimation of tinidazole and ciprofioxacin hydrochloride from their tablets has been developed. This chromatographic method utilises a 12.5 cm Nucleosil 100-5C18 bonded phase column with a mobile phase consisting of acetonitrile:methanol:0.002 M phosphoric acid (20:30:50) at a flow rate of 1.2 ml/min. Caffeine was used as the internal standard. Results of analysis gave standard deviation values below 1.5 and recovery study values between 98 to 103 per cent. Thus the method is suitable for routine analysis of multicomponent formulations of these two drugs.

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