All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Hydrolytic degradation profile and RP-HPLC estimation of cilostazol in tablet dosage form

Author(s): PK Basniwal1, PK Shrivastava2, Deepti Jain2
1LBS College of Pharmacy, Tilak Nagar, Jaipur-302 004, India 2School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya (University of Technology of MP), Gandhinagar, Bhopal-462 036, India

Correspondence Address:
P K Basniwal LBS College of Pharmacy, Tilak Nagar, Jaipur-302 004 India E-mail: [email protected]

A simple, selective, precise and stability-indicating high-performance liquid-chromatographic method of analysis of cilostazol in pharmaceutical dosage form was developed and validated. The solvent system consisted of 10 mM phosphate buffer (pH 6.0):acetonitrile:methanol (20:40:40). Retention time of cilostazol in C18 column was 5.7 ± 0.1 min at the flow rate 1.3 ml/min. Cilostazol was detected at 248 nm at room temperature. The linear regression analysis data for the calibration plots showed good linear relationship with correlation coefficient value, r 2 =0.9998 in the concentration range 100-3200 ng/ml with slope 43.45 intercept 156.75. The method was validated for linearity, range, accuracy, precision and specificity. Cilostazol was determined in tablet dosage form in range of 99.58-100.67% with 0.4600 standard deviation. Stress studies were conducted in acid and alkali hydrolysis with gradual increasing concentration. Cilostazol was found to be stable in various concentrations of acidic and alkaline.

Full-Text | PDF

Google scholar citation report
Citations : 53647

Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report