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Abstract

Importance Of Docking Studies In Drug Design

Author(s): K. G Bothara, A. U Patil, A Sexena

Docking Studies have become nearly indispensable for study of macromolecular structures and interactions. Mechanical model construction requires heroic patience and endurance to complete a structure which may contain several thousand atoms while computer graphics can build and display in seconds. Macromolecular modeling by Docking studies provides most detailed possible view of drug-receptor interaction and has created a new rational approach to drug design where the structure of drug is designed based on its fit to three dimensional structures of receptor site, rather than by analogy to other active structures or random leads.

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