In vitro antiviral activity of some novel isatin derivatives against HCV and SARS-CoV viruses

P Selvam1; N Murgesh2; M Ch; ramohan3; E De Clercq4; E Keyaerts4; L Vijgen4; P Maes4; J Neyts4; MV Ranst4

doi:10.4103/0250-474X.4033

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Abstract

In vitro antiviral activity of some novel isatin derivatives against HCV and SARS-CoV viruses

Author(s): P Selvam¹, N Murgesh², M Chandramohan³, E De Clercq⁴, E Keyaerts⁴, L Vijgen⁴, P Maes4, J Neyts⁴, MV Ranst⁴
¹Arulmigu Kalasalingam College of Pharmacy, Krishnankoil - 626 190, India ²Institute of Pharmacology, Madurai Medical College, Madurai - 625 020, India ³Bharat Ratna Kamarajar Liver Hospital and Research Center, Madurai - 625 001, India ⁴Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000, Belgium

Correspondence Address:
P Selvam, Arulmigu Kalasalingam College of Pharmacy, India, E-mail: periyasamyselvam2001@yahoo.co.in

DOI: 10.4103/0250-474X.4033

4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 µg/ml, without toxicity at a concentration up to 42 µg/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.

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