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Abstract
In vitro dissolution rate enhancement of a combination of drugs via solid dispersion
Author(s): NK Jain, RH Parikh
Dept. of Pharmacy, The M.S. University of Baroda, Baroda-390 001,
Correspondence Address:
N K Jain Dept. of Pharmacy, The M.S. University of Baroda, Baroda-390 001
Dept. of Pharmacy, The M.S. University of Baroda, Baroda-390 001,
Correspondence Address:
N K Jain Dept. of Pharmacy, The M.S. University of Baroda, Baroda-390 001
Solid dispersions of a combination of sulphamethoxazole (SMZ) and trimethoprim (TMP) were prepared using PEG6000 as carrier, by fusion method. PEG6000 does not interact with the drugs increases the solubility of both the drugs appreciably. SMZ exhibits faster dissolution from solid dispersions but dissolution rate of TMP is not altered significantly.
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