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Abstract

In Vitro Premeation Study Of Diclofenac Hydroxyethyl Pyrrolidine

Author(s): S. P Patvardhan, K. S Joshi, V. S. V Vadlamudi Rao, S. G Deshpande

In vitro diffusion of diclofenac hydroxyethyl pyrrolidine (DHEP), a novel salt of a known non-steroidal anti-inflammatory drug (NSAID) was carried out using 'Valia-Chien' glass diffusion cell assembly. Effect of penetration enhancers such as d-(+)-limonene, oleic acid, deet, isopropyl myristate (IPM) on the flux of DHEP was studied by carrying out in vitro permeation studies in presence of these enhancers. The enhancement brought about by d (+)-limonene was approximately 17 times and IPM enhanced flux 5 times, deet 3 times, oleic acid 2 times when compared to flux of DHEP alone. These findings helped in the selection of proper penetration enhancers to be incorporated in semi-solid formulations containing DHEP.

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