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Abstract

In Vitro Study Of The Effect Of Paracetamol On Drug-Protein Interactions

Author(s): Neelam Seedher, Suresh Kumar

Association constants for the binding of six drugs to serum albumin have been studied in the absence and presence of paracetamol using ultraviolet absorption spectroscopic technique. Paracetamol is found to influence the binding behaviour of other drugs by non-competitive interference involving structural changes in the albumin molecule. Significant increase in the concentration of free drug has been observed for metronidazole and promethazine hydrochloride in the presence of paracetamol. Ratio of association constants in the presence and absence of paracetamol can be used as a guide to the modified design of dosage forms in the presence of paracetamol.

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