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Inclusion Complexation Of Ketoprofen With b-Cyclodextrins

Author(s): P. R Vavia, P. T Tayade

Ketoprofen, a non-steroidal anti-inflammatory agent, is chemically a propionic acid derivative having poor aqueous solubility. This study describes method of inclusion complexation of ketoprofen with b-cyclodextrin (b-CD) and hydroxypropyl b-cyclodextrin (HP-b-CD). The solid complexes were prepared by various methodologies such as physical mixture, co-precipitation, kneading and freeze drying. The drug and cyclodextrins were used in molar ratio of 1:1. These complexes were characterized by U.V., FT-IR, 1H-NMR Spectroscopy, Differential Scanning Calorimetry, and X-ray diffractometry. Freeze drying method was found to be the method of choice for successful inclusion complexation of Ketoprofen with b-CD and HP-b -CD.


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