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Abstract

Inducible Nitric Oxide Synthase (iNOS) Inhibitors From Plants

Author(s): Neerja Pant, D. C Jain

Nitric Oxide (NO), a gas at temperatures below –152º has long since been known as a toxic smog pollutant. Present reports furnish the fact that nitric oxide is synthesized in many cells endogenously. While the endogenous production of NO may significantly benefit an organism, its excessive production has been implicated in the pathogenesis of many diseases involving the cardiovascular, immune and nervous system. Inhibition of NO formation may have therapeutic benefit in patients with septic shock or inflammatory diseases. Phytochemicals Isolated from various medicinally important plants provide valuable agents that suppress the expression of inducible nitric oxide synthase (iNOS) enzyme which are hence useful for the prevention of various diseases. Systematic work performed during the last decade has been reviewed and tabulated in this article.

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