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Abstract

Influence Of Granule Size And Lubricant Concentration On The Dissolution Of Paracetamol Tablets

Author(s): S.C Basak, T Sivakamasundari, S Sivagamasundari, R Manavalan

The effects of granule size and concentration of magnesium stearate as lubricant on the dissolution rate of paracetamol tablets were studied. The results obtained show that dissolution rate was increased as the granule size of the tablet was increased for tablets prepared with 1.5% magnesium stearate as lubricant. However, tablets prepared with different granule size, exhibited no pronounced effect on the dissolution characteristics when concentration of magnesium stearate was used as 0.75%.

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