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Inhibitory Effect of Blueberry Anthocyanins on Human Gastric Adenocarcinoma Cells and Transplanted Tumor in Nude Mice by Regulating the Endogenous Apoptosis Pathway

Author(s): Shibo Huang, Minghui Li, Dan Jin and Yingming Xie*
Department of Gastrointestinal Surgery, 1Department of Medical Oncology, Beidahuang Industry Group General Hospital, Harbin, Heilongjiang Province 150001, 2Department of Respiratory Medicine, Harbin Institute of Technology Hospital, Harbin, Heilongjiang Province 150006, China

Correspondence Address:
Yingming Xie, Department of Respiratory Medicine, Harbin Institute of Technology Hospital, Harbin, Heilongjiang Province 150006, China, E-mail:

This article investigated the endogenous mechanism of blueberry anthocyanins in regulating apoptosis through growth inhibition of human gastric adenocarcinoma BGC-823 and their xenograft tumors in nude mice. The Massachusetts Institute of Technology and terminal deoxynucleotidyl transferase dUTP nick end labeling methods were used to detect the proliferation and apoptosis of human gastric adenocarcinoma BGC-823. The nude mice BGC823 human gastric adenocarcinoma xenograft tumor model was established and treated with blueberry anthocyanins of 0 μg/ml, 50 μg/ml and 100 μg/ml, respectively. The expression of B-cell lymphoma 2, B-cell lymphoma 2 associated X-protein, and p-c-Jun N-terminal kinase protein in nude mice transplanted with human gastric adenocarcinoma cells was detected by Western blot. The proliferation inhibition rate and apoptosis rate of human gastric adenocarcinoma BGC-823 gradually increased with the increase of blueberry anthocyanins concentration; blueberry anthocyanins could reduce the growth of transplanted tumor in nude mice; blueberry anthocyanins decrease the B-cell lymphoma 2 protein and increase the Bcl-2 associated X-protein and p-c-Jun N-terminal kinase protein in the tumor tissue of nude mice with n human gastric adenocarcinoma transplanted tumor model (all p<0.05). Blueberry anthocyanins can inhibit the proliferation of BGC-823 and the growth of transplanted tumors, and may play a positive role in inhibiting human gastric adenocarcinoma by regulating the c-Jun N-terminal kinase signaling pathway.

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