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Abstract

Interaction of platelets with invertebrate and lower vertebrate collagens.

Author(s): DV Ramesh
Biomaterials Laboratory, Central Leather Research Institute, Adyar, Madras 600 020,

Correspondence Address:
D V Ramesh Biomaterials Laboratory, Central Leather Research Institute, Adyar, Madras 600 020

Collagens from the skins of Sepia officinalys, an invertebrate, mollusc and Cybium guttatum a marine fish (lower vertebrate) were extracted. The aggregation of platelets by these collagens was investigated and compared with the induction of platelet aggregation by vertebrate collagen. The collagens from invertebrate and lower vertebrate were found to induce platelete aggregation as actively as vertebrate collagen. The lower vertebrate collagen showed highest aggregation when compared to other collagens suggesting that it can be used as a better hemostatic agent.

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