Interaction of platelets with invertebrate and lower vertebrate collagens.
Biomaterials Laboratory, Central Leather Research Institute, Adyar, Madras 600 020,
D V Ramesh Biomaterials Laboratory, Central Leather Research Institute, Adyar, Madras 600 020
Collagens from the skins of Sepia officinalys, an invertebrate, mollusc and Cybium guttatum a marine fish (lower vertebrate) were extracted. The aggregation of platelets by these collagens was investigated and compared with the induction of platelet aggregation by vertebrate collagen. The collagens from invertebrate and lower vertebrate were found to induce platelete aggregation as actively as vertebrate collagen. The lower vertebrate collagen showed highest aggregation when compared to other collagens suggesting that it can be used as a better hemostatic agent.PDF