All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Intestinal Permeability of Lamivudine Using Single Pass Intestinal Perfusion

Author(s): JR Patel, Kalyani H Barve

The intestinal transport of lamivudine, a nucleotide reverse transcriptase inhibitor, was investigated using the single pass intestinal perfusion technique in male Wistar rats. Single pass intestinal perfusion was performed in small intestine at a flow rate of 0.20 ml/min. Lamivudine exhibits a high intestinal permeability over the length of the small intestine indicative of compounds that are well absorbed. The Peff of lamivudine is in the range of drugs with high intestinal permeability and high fraction of dose absorbed indicating that lamivudine readily crosses the intestine. This also suggests that lamivudine belongs to biopharmaceutics classification system class I and is a good candidate for biopharmaceutics classification system based biowaiver. The permeability values obtained from this study may be useful in models of exposure assessment.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report