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Isolation and Synthesis of 2-Phenyl Benzopyranones and Comparative Evaluation Of Their Smooth Muscle Relaxant Activity

Author(s): S L Achar, G M Padma Rao, K K Srinivasan

A few 2-phenyl benzopyranones (substituted flavanones) were isolated from the available sources or synthesized by simple base catalyzed condensation of appropriate aryl aldehydes and substituted 2'-hydroxy acetophenones. The effect of these substituted flavanones on contraction evoked by oxytocin, on rat uterus was studied. Of the isolated/synthesized compounds, naringenin showed maximum inhibition of oxytocin-induced contraction of rat uterus.