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Kinetics And Tissue Distribution Of Niosomal Bleomycin In Tumour Bearing Mice

Author(s): R. A Raja Naresh, N Udupa, P Uma Devi

Bleomcyin was encapsulated in niosomes and administered to tumor bearing mice. The plasma kinetics and tissue distribution of niosomal bleomocycin was studied in tumor bearing mice. The noisome encapsulated bleomycin was cleared from the plasma much more slowly than was the free drug. A significant increase in plasma concentration of bleomycin was achieved in mice when it was administered niosomes as compared to free drug. The tumour bleomycin level enhanced significantly.


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