All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Kinetics of autoxidation of an oil extract from Terminalia catappa

Author(s): EO Omeje1, GB Okide1, CO Esimone2, U Ajali1
1Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka-410001, Nsukka, Nigeria 2Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka-410001, Nsukka, Nigeria

Correspondence Address:
E O Omeje Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka-410001, Nsukka Nigeria E-mail: winnomeje@yahoo.com


Soxhlet extractor was used in the extraction of oil from milled seeds of Terminalia catappa using petroleum ether (40-60°). The optimal oil yield was 56.71±1.66% with a viscosity of 40.79±1.05 centipoises. Other parameters of the oil were found as follows; specific gravity-0.9248, refractive index-1.4646, acid value-3.35, peroxide value-8.6, saponification value-166.2, and unsaponifiable matter-1.46. The crude oil extract was water-degummed, bleached and deodorized to generate what we called refined oil. Autoxidation of the crude and refined T. catappa oil extract was done at five different temperatures of 0±0.1°, 20±0.1°, 40±0.1°, 60±0.1° and 80±0.1° and also in the presence of pure a-tocopherol at a concentration of 1.0% (w/v) by measuring peroxide value variations over 96 h. In all evaluations, the refined oil exhibited lower tendency towards autoxidation but not at temperatures above 60±0.1°. The use of Arrhenius equation revealed generally very low activation energies of 0.0261 cal/deg×mol and 0.0122 cal/deg×mol for crude oil and antioxidant-treated crude oil, respectively and 0.0690 cal/deg×mol and 0.0177 cal/deg×mol for the refined oil. This study indicates T. catappa seed oil to be potential pharmaceutical oil with excellent characteristics.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report