All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Liver X Receptor: A novel therapeutic target

Author(s): MB Patel, NA Oza, IS Anand, SS Deshpande, CN Patel
Department of Pharmacology, Shri Sarvajanik Pharmacy College, Near Arvind Baug, Mehsana - 384 001, India

Correspondence Address:
M B Patel Department of Pharmacology, Shri Sarvajanik Pharmacy College, Near Arvind Baug, Mehsana - 384 001 India E-mail: [email protected]


The liver X receptors α and β are orphan nuclear receptors that are key regulators in maintaining cholesterol homeostasis. Originally they were found to play an important role in reverse cholesterol transport, a pathway for the removal of excess cellular cholesterol. However several groups have now shown that the liver X receptors also functions in lipid and carbohydrate metabolism, cellular differentiation, apoptosis and many immune responses. Tissue distribution of the two paralogues differs with liver X receptor β ubiquitously expressed, while liver X receptor α is confined to the liver, kidney, intestine, spleen, adipose tissue, macrophages and skeletal muscle. The endogenous ligands for the liver X receptors are certain oxidized derivatives of cholesterol, the oxysterols. Upon activation by oxysterols, the receptors form obligate heterodimers with retinoid X receptors α, β and γ; and become competent to activate the transcription of target genes.

Full-Text | PDF