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Abstract

Long Noncoding RNA ENST00000581794.1 in Peripheral Blood Mononuclear Cells Acts as a Novel Biomarker in Patients with Acute Myocardial Infarction

Author(s): Z. XUE-HE, QIAN ZHAO, NING SONG1, JUN-YI LUO1, C. QING-JIE1, A. CHENC2, MUNIRE TUXUN, G. AIHEMAITI AND XIAO-MEI LI1*
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Cardiology, 1Xinjiang Key Laboratory of Cardiovascular Disease Research, Clinical Medical Research Institute of First Affiliated Hospital of Xinjiang Medical University, Urumqi, China, 2Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing, China

Correspondence Address:
1Xinjiang Key Laboratory of Cardiovascular Disease Research, Clinical Medical Research Institute of First Affiliated Hospital of Xinjiang Medical University, Urumqi, China, E-mail: [email protected]

The aim of this investigation is to investigate the long noncoding ribonucleic acid and mRNA expression profiles of acute myocardial infarction patients and matched healthy controls particularly the higher-ranked long noncoding ribonucleic acid ENST00000581794.1 in co-expression. This study group found that ENST00000581794.1 was up-regulated in acute myocardial infarction patients in pre-experiment. It is suggested that ENST00000581794.1 may be a potential biomarker of acute myocardial infarction. Fifty eight patients with acute myocardial infarction and 58 healthy controls were included in this study from September 2017 to February 2018. Venous blood samples were collected from patients within 6 h from the onset of chest pain and RT-qPCR measured the expression levels of long noncoding ribonucleic acid in peripheral blood mononuclear cells. All patients were followed for 12±1 mo. The expression levels of ENST00000581794.1 were significantly different between the two groups. The receiver operating characteristic curve showed that long noncoding ribonucleic acid ENST00000581794.1 (area under the curve = 0.744, 95 % confidence interval: 0.61~0.88, p=0.004) had a predictive effect on major adverse cardiovascular events. Survival curve analysis demonstrated that the incidence of major adverse cardiovascular events became significantly higher in patients with high expression of ENST00000581794.1 as the observation time increased. Multivariate regression analysis indicated that ENST00000581794.1 was an independent predictor of major adverse cardiovascular events in patients with acute myocardial infarction (hazard ratio: 1.17, 95 % confidence interval: 1.00~1.37, p=0.048). Highly expressed ENST00000581794.1 in peripheral blood mononuclear cells may be used as a biomarker for diagnosis and prognosis of acute myocardial infarction.

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