Microbial conversion of coumarin.
University of Mansoura, College of Pharmacy, Dept. of Pharmacognosy, Mansoura 35516, Egypt
S H El-Sharkawy University of Mansoura, College of Pharmacy, Dept. of Pharmacognosy, Mansoura 35516, Egypt
Coumarin was converted by Glecocladium roseum NRRL 1859 into three metabolities 4-hydroxycoumarin, 7-hydroxycoumarin and 6,7- dihydroxy-coumarin-6-glucoside in 21 percent, 26 percent and 10.5 percent yield, respectively. 7-methoxycoumarin was obtained (13 percent) by transformation of coumarin by C. tropicalis. The identity of the isolated metabolites were established using mp, ms, uv and both H- and C-NMR spectral analysis.PDF