All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Microencapsulation of zidovudine by double emulsion solvent diffusion technique using ethylcellulose

Author(s): MK Das, K Rama Rao
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh - 786 004, India

Correspondence Address:
M K Das Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh - 786 004 India E-mail: [email protected]


Zidovudine-ethylcellulose microspheres were prepared by water-in-oil-in-oil double emulsion solvent diffusion method. Spherical free flowing microspheres having an entrapment efficiency of 32-54% were obtained. The effect of polymer-drug ratio, surfactant concentration for secondary emulsification process, volume of processing medium and stirring speed of secondary emulsification process was evaluated with respect to entrapment efficiency and in vitro drug release behaviors. Infrared spectroscopy and differential scanning calorimetric analysis confirmed the absence of any drug polymer interaction. The in vitro release profile could be altered significantly by changing various processing and formulation parameters to give a controlled release of drug from the microspheres. The in vitro release profiles from microspheres of different polymer-drug ratios were applied on various kinetic models. The best fit with the highest correlation coefficient was observed in higuchi model, indicating diffusion-controlled principle. The n value varies between 0.23-0.54 obtained from korsemeyer-peppas model confirmed that the mechanism of drug release was diffusion controlled.

PDF

 
 
List of Supporting Conferences