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Microwave Assisted Synthesis And Antimicrobial Screening Of 2-Aryl-5H-3-(3',5'-Dichioro-2-Benzo(b)Thiophenoylamino)-4-Thiazolidinones

Author(s): K.M Thaker, S.L Vasoya, K.S Nimavat, H.S Joshi

The synthesis of some new potentially bioactive 4-thiazolidinone has been undertaken. The required 2-(substituted benzalhydrazinocarbonyl)-3,5-dichloro-benzo(b)thiophene(2) was prepared by reaction of 2-hydrazinocarbonyl-3,5-dichloro benzo(b)thiophene(1) with different aryl aldehyde. The compounds (2) on cyclocondensation with thioglycolic acid under micro wave irradiation as well as In a conventional way yielded the corresponding 4-thiazolidinones (3). The structures of synthesized compounds were deduced on the basis of their elemental analyses and spectral analyses (IR and 1H NLIR). The synthesized compounds were evaluated for their antimicrobial activity.


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