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Abstract
Microwave assisted synthesis and pharmacological evaluation of some potent naphtho and benzofuro thiazolyl, oxazolyl, thio and oxadiazalyl derivatives
Author(s): DB Aruna Kumar1, GK Prakash2, BP Nandeshwarappa3, BM Kiran1, BS Sherigara3, KM Mahadevan1
1 Department of PG Studies and Research in Chemistry, School of Chemical Sciences, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, India 2 Institute of Wood Science and Technology, Malleshwaram, Bangalore-560 003, India 3 Department of PG Studies and Research in Industrial Chemistry, School of Chemical Sciences, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, India
Correspondence Address:
K M Mahadevan Department of PG Studies and Research in Chemistry, School of Chemical Sciences, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451 India E-mail: mady_kmm@yahoo.co.uk
1 Department of PG Studies and Research in Chemistry, School of Chemical Sciences, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, India 2 Institute of Wood Science and Technology, Malleshwaram, Bangalore-560 003, India 3 Department of PG Studies and Research in Industrial Chemistry, School of Chemical Sciences, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, India
Correspondence Address:
K M Mahadevan Department of PG Studies and Research in Chemistry, School of Chemical Sciences, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451 India E-mail: mady_kmm@yahoo.co.uk
The substituted 2-acetyl benzofurans on bromination gave substituted 2-(2-bromoacetyl) benzofurans 2a-f. These on reaction with thiourea, urea, thiosemicarbazide and semicarbazide in presence of sodium acetate under microwave irradiation resulted 3a-f, 4a-f, 5a-f and 6a-f respectively. The structures of newly synthesised compounds have been established by elemental analysis, spectral data and screened for antimicrobial, anthelmintic, antiinflammatory and analgesic activities.
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