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Microwave Assisted Synthesis Of New Bioactive 1,3,4-Thiadiazolyl Substituted 1,3,4-Oxadiazoles

Author(s): M Kidwai, Y Goel, P Kumar

A series of new 2- [5'- methyl-1, 3,4-thiadiazolyl] -5-aryl-1,3,4-oxadiazoles have been synthesised by the reaction of 5-methyl-1,3,4-thiadiazolyl-2-thioacetic acid hydrazide with appropriate aromatic acids in SoCl2 under microwave irradiation in open vessels using a domestic microwave oven as compared to the conventional method. The reaction rate has been improved tremendously. These oxadiazoles have shown promising antifungal activity against A. niger and A. Flavous.


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