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Abstract
Molecular Inclusion Of Sparfloxacin With Hydroxypropyl Beta Cyclodextrin
Author(s): V. K Mourya, T. R Saini, V Balasubramaniyam, J. S Shete, G. S Jadhav
The formation of an inclusion complex between hydroxypropyl-β-cyclodextrin and sparfloxacin is described. The 1:1 stoichiometry of the components is suggested by phase solubility studies and Benesi-Hildebrand plot showing the regression y=0.0087x+32.273 with the coefficient of correlation 0.7706 at slit width 1 nm. Stability constant evaluated by phase solubility analysis and Benesi-Hildebrand plot showed deviations. Thermodynamic parameters for the inclusion complex have been also estimated. The formation of the complex is detected by differential scanning calorimetry, potentiometry, UV, FTlR and fluorescence spectral methods. The complex displays enhanced aqueous solubility and dissolution.
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