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Abstract

Molecular Mechanism of the Protective Effect of Salvia Miltiorrhiza Extract on Traumatic Arthritis and Its Effect on Tumor Necrosis Factor-Alpha

Author(s): Yinchuan Ma, Xiaobin Li and Fuqiang Tan*
Second Department of Orthopedics, Zhongxian People???s Hospital, Chongqing 404300, 1Department of Orthopedics, People's Hospital of Chongqing Hechuan, Chongqing 401519, China

Correspondence Address:
Fuqiang Tan, Department of Orthopedics, People's Hospital of Chongqing Hechuan, Chongqing 401519, China, E-mail: fuqiangtan2023@163.com


Traumatic arthritis is a common joint disease. Salvia miltiorrhiza is a traditional Chinese medicine that has been used for the treatment of cardiovascular diseases and inflammation-related diseases. However, the efficacy and mechanism of Salvia miltiorrhiza extract on traumatic arthritis are still unclear. 60 rats were randomly divided into controls, traumatic arthritis group, and of Salvia miltiorrhiza extract treatment group. Traumatic arthritis model was established in groups B and C, and of Salvia miltiorrhiza extract was administered in group C. The expression levels of arthritis markers and inflammation-related factors were detected. Relative to group B, the relative expression level of serum malondialdehyde in group C was apparently decreased, and that of serum superoxide dismutase was apparently raised. The serum levels of tumor necrosis factor-alpha and nitric oxide in group C were apparently lower as against group B (p<0.05). In addition, the level of serum nuclear factor-kappa B protein in group C was apparently decreased, and the level of inhibitor of nuclear factor-kappa B was apparently raised (p<0.05). Salvia miltiorrhiza extract has a protective outcome on traumatic arthritis and can reduce the inflammatory response. Salvia miltiorrhiza extract can regulate inflammatory signaling pathways, and especially inhibit the expression of tumor necrosis factor-alpha.

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