All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Multidrug Resistance : The Role Of The ATP-Binding Cassette Superfamily Transport Protein, P-Glycoprotein

Author(s): A. A Joshi, C. L Viswanathan

Multidrug resistance is a condition in which cells exhibit resistance to drugs to which they have never been exposed to previously. The main factor contributing to this is the overexpression of an energy-dependant multidrug transporter, P-glycoprotein. P-glycoprotein is also involved in the normal physiological functions. P-glycoprotein is widely distributed in the body and found in organs like lower gastrointestinal tract, kidney, liver, pancreas, testes and most importantly, the blood-brain barrier. Although, many mechanisms have been promulgated which involve P-glycoprotein in multidrug resistance, there is no satisfactory mechanism that reconciles the entire phenomenon related to multidrug resistance. Efforts have also been taken to isolate, characterize and spectroscopically analyze P-glycoprotein. Based on the available data, there are many agents, which are proven to be the substrates of P-glycoprotein. Moreover, there also are inhibitors to Pglycoprotein that enhance the intracellular levels of many drugs that are effluxed by P-glycoprotein.

PDF

 
 
List of Supporting Conferences