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New Spectrophotometric Analysis Of Atenolol In Pure And Pharmaceutical Formulations

Author(s): U Viplava Prasad, G. V Rao, S. P Sastry

Two simple and sensitive spectrophotometric methods (A and B) for the determination of atenolol in bulk samples and pharmaceutical formulations are described. Both the methods are based on the oxidation of the drug with excess quantities of oxidants, N-bromosuccinimide (NBS) in method A and nitrous acid in method B. The excess NBS in method A is determined using a dye celestine CB blue at 1max 540 nm, while in method B the excess nitrous acid is determined using a dye cresyl fast violet acetate CFVA 1max 555 nm. Both these methods are applicable to pure samples as well as formulations of the drug. The results obtained by the proposed methods were in good agreement with the labelled amounts.


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