All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

New Spectrophotometric Methods For The Determination Of Nimesulide

Author(s): K. P. R Chowdary, K Girish Kumar, G Devala Rao

Two simple and sensitive spectrophotometric methods (A and B) in the visible region have been developed for the determination of nimesulide in bulk and in dosage forms. Method A is based on the reaction of reduced nimesulide with nitrous acid followed by its coupling with phloroglucinol to yield an yellow colored azo dye with an absorption maximum of 400 nm and method B is based on the reaction of reduced nimesulide with p-dimethylamino benzaldehyde (PDAB) to form an yellow colored chromogen wiht an absorption maximum of 415 nm. The color obeyed Beer's law in the concentration range of 4-20 mg/ml in method A and 4-24 mg/mI in method B. When pharmaceutical preparations (Tablets and suspension) were analysed, the results obtained by the proposed methods are in good agreement with the labelled amounts and are comparable with the results obtained by a reported method. Recovery in both the methods is 98-101%.

PDF

 
 
Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report