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Abstract
Newer thiobarbiturates as anti-inflammatory agents.
Author(s): R Kalsi, K Pande, TN Bhalla, JP Barthwal
Dept. of Pharmacology and Therapeutics, King George's Medical College, Lucknow-226 003,
Correspondence Address:
R Kalsi Dept. of Pharmacology and Therapeutics, King George's Medical College, Lucknow-226 003
Dept. of Pharmacology and Therapeutics, King George's Medical College, Lucknow-226 003,
Correspondence Address:
R Kalsi Dept. of Pharmacology and Therapeutics, King George's Medical College, Lucknow-226 003
1-Aryl-3-(2-methyl-4-(1H-indol-3-yl-methylene)-2-imidazolin-5-one-1-yl ) thiobarbituric acid (IIIa-b). prepared by cyclization of corresponding thiourea (IIa-b) with malonic acid and acetyl chloride yielded (IV and V) when subjected to Mannich and Knoevenagel reaction respectively. All the compounds were screened for their anti-inflammatory and ulcerogenic activities with non-steroidal anti-inflammatory drugs (NSAIDS).
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