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Abstract

Nondestructive and rapid concurrent estimation of paracetamol and nimesulide in their combined dosage form using raman spectroscopic technique

Author(s): Gargi R Lakhwani, OD Sherikar, Priti J Mehta
Department of Pharmaceutical Analysis, Institute of Pharmacy, Nirma University, Ahmedabad 382 481, India

Correspondence Address:
Priti J Mehta Department of Pharmaceutical Analysis, Institute of Pharmacy, Nirma University, Ahmedabad 382 481 India E‑mail: [email protected]


A rapid, nondestructive Raman spectroscopic method was developed for quantitative estimation of paracetamol and nimesulide in their combined dosage form. A Raman univariate calibration model was developed by measuring the peak intensities of paracetamol and nimesulide at 853 cm−1 and 1336 cm−1 , respectively. The developed method was successfully applied for in situ, concurrent estimation of paracetamol and nimesulide in their combined dosage and method was also validated according to International Conference on Harmonisation guidelines. Thus, the developed Raman spectroscopic method can be applied for simultaneous estimation of paracetamol and nimesulide in their combined dosage form as a process analytical technology tool by pharmaceutical industries for routine quality control.

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