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Novel Method Of Synthesis Of Curcuminoids And Derivative Of Ibuprofen As Potent Antiinflammatory Agent

Author(s): P Jayasekhar, S. B Rao, G Santhakumari

A novel method of synthesis of curcumin-I has been successfully developed using Claisen- Dieckmann condensation where dehydrozingerone is condensed with methyl ferulate in presence of sodium ethoxide In dimethyl sulphoxide. Various curcuminoids are prepared by changing the esters and α, β-unsaturated ketones. This reaction is utilized to prepare dehydrozingerone- ibuprofen condensation product (DZIBU), a potent antiinflammatory agent. The homogenecity of compounds synthesized was established and structures were confirmed by spectral data. DZIBU exhibited powerful antiinflammatory activity on carrageenan-induced paw edema model and formaldehyde-induced arthritis model in rats. Though the analgesic activity was less when compared to that of ibuprofen, the new compound did not induce gastrointestinal side effect In animal studies.


Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report