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Abstract

Observation of the Clinical Effect of Ureklin and Aspirin Combined with Rehabilitation Training in Patients with Acute Cerebral Infarction

Author(s): Jie Lin, Guangjie Li, Yichen Zhang, Huaiying Shi, Xun Gong, Libo Zhang, Xuanxuan Wang* and Xiaowei Wu
Department of Emergency Medicine, Wuhan No. 6 Hospital, Affiliated Hospital of Jianghan University, Wuhan, 1Medical Administration Division, Cadre Sanatorium of Hainan and Geriatric Hospital of Hainan (CSH), Haikou, 2Department of Biology, Shenzhen MSU-BIT University, Shenzhen, Guangdong, 3Nursing Department of Cadre Sanatorium of Hainan and Geriatric Hospital of Hainan (CSH), Haikou, 4School of Materials Science and Engineering, Shenyang Ligong University, 5Imaging Department, The General Hospital of Northern Theatre, Chinese People's Liberation Army, Shenyang, 6Department of Integrated Traditional Chinese and Western Medicine, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 7Department of Thoracic Surgery, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Correspondence Address:
Xuanxuan Wang Department of Emergency Medicine, Wuhan No. 6 Hospital, Affiliated Hospital of Jianghan University, Wuhan, China E-mail: mei8383451@163.com


To observe the clinical effect of ureklin and aspirin combined with rehabilitation training in patients with acute cerebral infarction. A total of 120 patients with acute cerebral infarction admitted to our hospital from January 2018 to January 2021 were randomly divided into control group and observation group. Both groups received conventional treatment. On this basis, the control group was treated with aspirin combined with rehabilitation training and the observation group was treated with aspirin combined with rehabilitation training and ureklin. The clinical efficacy after 2 w of treatment and safety during treatment of the two groups were counted and the level of serum cytokine, hemorheology, neurological function and quality of life were compared between the two groups before and after 2 w of treatment. After 2 w of treatment, the total effective rate of control group was lower than that of observation group (p<0.05). After 2 w of treatment, level of serum vascular endothelial growth factor and scores of activity of daily living and Barthel index in both groups were higher than before treatment and there was statistical difference between observation group and control group (p<0.05). After 2 w of treatment, levels of serum homocysteine, cystatin-C, plasma viscosity, platelet aggregation rate, hematocrit, fibrin and score of National Institutes of Health Stroke Scale in both groups were lower than those before treatment and there was statistical difference between observation group and control group (p<0.05). During treatment, the total incidence of adverse reactions in the observation group was 6.67 % and there was no significant difference between the observation group and the control group (11.67 %, p>0.05). Ureklin and aspirin combined with rehabilitation training could effectively improve the synthesis of serum cytokines, hemorheology and neurological function in patients with acute cerebral infarction and improve the quality of life of patients, with better clinical efficacy.

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