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Abstract

Overexpression of C1QTNF6 in Esophageal Cancer and Promotes the Proliferation and Migration of Esophageal Cancer Cells

Author(s): H. F. Xia, F. Lu, X. J. Yu, Y. Feng and H. T. Ma*
Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, 1Department of Cardiothoracic Surgery, Suzhou Dushuhu Public Hospital, Suzhou, Jiangsu 215006, China

Correspondence Address:
H. T. Ma, Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China, E-mail: haitaomasoochow@163.com


Esophageal cancer is a common cancer among people in the world. The molecular mechanism of complement C1q tumor necrosis factor related protein 6 in esophageal cancer is still unclear. This article aimed to clarify the role of complement C1q tumor necrosis factor related protein 6 in esophageal cancer. The expression of complement C1q tumor necrosis factor related protein 6 in esophageal cancer tissues was detected using quantitative real-time polymerase chain reaction and Western blot. Furthermore, short hairpin ribonucleic acid was used to knockdown the expression of complement C1q tumor necrosis factor related protein 6 in esophageal cancer cell lines. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide, wound healing assays and transwell assays were used to determine the role of complement C1q tumor necrosis factor related protein 6 in esophageal cancer cells. In our research, we found that the expression of complement C1q tumor necrosis factor related protein 6 was up-regulated in esophageal cancer tissues. The increased expression of complement C1q tumor necrosis factor related protein 6 was significantly correlated with tumor stage and lymph node metastasis. The proliferation and migration of esophageal cancer cells were inhibited after complement C1q tumor necrosis factor related protein 6-short hairpin ribonucleic acid transfection in vitro. These results suggested that complement C1q tumor necrosis factor related protein 6 serves as an oncogene and promotes cell proliferation and migration in esophageal cancer. In addition, complement C1q tumor necrosis factor related protein 6 may be a potential therapeutic target for esophageal cancer patients.

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