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Permeability Of Ethylene Vinyl Acetate Copolymer Microcapsules : Effect Of Solvents

Author(s): K.P.R Chowdary, J Suri Babu

Ethylene vinyl acetate copolymer microcapsules of lndomethacin were prepared by an emulslflcation- solvent evaporation method employing chloroform or cyclohexane or dlchloromethane or 1,2-dichloroethane as solvent for the polymer ethylene vinyl acetate and the microcapsules were studied. All the microcapsules were spherical, discrete and free flowing. The microencapsulation efficiency was relatively high when chloroform was used as solvent. lndomethacin release from the microcapsules was slow and extended over more than 12 h. Drug release from all the microcapsules was diffusion controlled and followed first order kinetics. The solvent employed has significant influence on the permeability and drug release from the microcapsules. The order of increasing permeability of ethylene vinyl acetate microcapsules prepared employing various solvents was cyclohexane


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