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Permeation Of Diclofenac Through Buccal Mucosa

Author(s): J. K Lalla, Rita A Gurnaney, S Narayanan

Permeability coefficient, flux and other related values of diclofenac potassium through guinea pig buccal mucosa have been compared with those obtained through porcine buccal mucosa at pH 6.8 and 8.0 The permeation values of the species of diclofenac potassium have also been compared with diclofenac diethyl ammonium salt. Rodent buccal pouch being keratinised showed very poor permeation. Permeation through porcine buccal pouch at pH 6.8 and 8.0 was not significantly different. Permeability coefficient values were significantly higher for diclofenac potassium than those for diclofenac diethyl ammonium salt. Use of 5% polysorbate 80 significantly enhanced the permeation of diclofenac potassium.


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