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Abstract

Pharmaceutical Application Of Starch Isolated From Nelumbo Nucifera Gaertn (Fam. Nymphaeaceae)

Author(s): Pulok K Mukherjee, S. N Giri, Kakali Saha, M. S Dutta, M Pal, B. P Saha

A study has been carried out to investigate the binding and disintegrating properties of starch isolated from rhizomes of Nelumbo nucifera (Nelumbo starch) along with the dissolution rate profiles. For this study the tablets of Paracetamol (500 mg), metronidazole (400 mg) and ibuprofen (400 mg) were prepared using maize, nelumbo and potato starch, each in batches of 200. All the products met the requirement of in vitro parameters such as uniformity of weight, assay, friability and hardness as per Pharmacopoeial requirements. These products also conform the dissolution specification of USP. The amounts of Nelumbostarch required as binding and disintegrating agent was half of the amount of maize and potato starch. Therefore Nelumbo starch can be effectively used in tablet technology.

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