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Abstract

Pharmacological Screening Of 6H, 11H-Indolo [3, 2-c] Isoquinolin-5-Ones And Their Derivatives

Author(s): A. R Saundane, K Rudresh, N. D Satyanarayan, S. P Hiremath

Fifteen different indolo[3,2-c]isoquinolin-5-ones and their derivatives prepared earlier were screened for analgesic, antiinflammatory, oxytocic, anthelmintic and antimicrobial activities. Compounds la,2a, 3a-b, 4a and 6c exhibited promising analgesic activity while compounds 1b and 2a-c showed maximum anti-inflammatory activity. The only compound that showed maximum anthelmintic activity is 3b.The compound 2b exhibited promising antibacterial activity against all the organisms tested. Whereas, compounds 1b, 3b and 5b showed high activity against E.coli. Antifungal activity revealed that compounds 5b and 5c were active against C. albicans, whereas, compounds 1c and 2b were found to be active against A. niger.

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