All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Pharmacological Screening Of Some Novel Isatin Derivatives

Author(s): P Selvam, A Rajasekaran, N Murugesh, M Chandramohan, E De Clerco

4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)-benzene Sulphonamide and its derivatives were evaluated for antibacterial activity, antifungal activity, antiviral activity against ten pathogenic viruses in E6SM, Vero and HeLa cells and anticancer activity against CNS, breast and lung cancer. The N-acetyl and 5-methyl derivatives showed a minimum inhibitory concentration (MIC) of 48 μg/ml against herpes simplex virus type-2 and respiratory syncytial virus, without toxicity at a concentration upto 400 μg/ml. The test compounds showed comparable antibacterial activity to that of the parent sulphadimidine, except for the 5-bromo and N-acetyl derivatives.


Google scholar citation report
Citations : 53647

Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report