Physiological Role, Distribution And Pharmacological Characteristics Of ?3-Adrenoceptorts : An Overview.
The existence of an atypical (non Î²1, non (Î²2) form of Î²-receptors in various tissues has been reported in several studies. Reports of responses produced by Î²-adrenoceptor antagonists suggested the existence of an atypical b-adrenoceptor (Î²3). Interest is currently growing in the future heterogeneity of b-adrenoceptors. Bearing in mind the additional potential for therapeutic advancement, this review summarizes the structure-function relationship, physiological role and tissue distribution of Î²3 -adrenoceptors. It also gives the introductory overview of pharmacological actions and clinical indications for treatment with b-adrenoceptor agonists.PDF