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Plantago ovata mucilage in the design of fast disintegrating tablets

Author(s): SB Shirsand1, Sarasija Suresh2, MS Para3, PV Swamy1, D Nagendra Kumar3
1 Department of Pharmaceutical Technology, H.K.E. Society's College of Pharmacy, Sedam Road, Gulbarga-585 105, India 2 Department of Pharmaceutics, Al-Ameen College of Pharmacy, Near Lal Bagh Main Gate, Hosur Road, Bangalore-560 027, India 3 S. V. E. T's College of Pharmacy, Humnabad-585 330, India

Correspondence Address:
S B Shirsand Department of Pharmaceutical Technology, H.K.E. Society's College of Pharmacy, Sedam Road, Gulbarga-585 105 India [email protected]

In the present work, fast disintegrating tablets of prochlorperazine maleate were designed with a view to enhance patient compliance by direct compression method. In this method mucilage of Plantago ovata and crospovidone were used as superdisintegrants (2-8% w/w) along with microcrystalline cellulose (20-60% w/w) and directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time (approximately 8 s), the two formulations were tested for the in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40º/75% relative humidity for 3 mo) and drug-excipient interaction (IR spectroscopy). Among the two promising formulations, the formulation prepared by using 8% w/w of Plantago ovata mucilage and 60% w/w of microcrystalline cellulose emerged as the overall best formulation (t 50% 3.3 min) based on the in vitro drug release characteristics compared to conventional commercial tablets formulation (t 50% 17.4 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro dispersion time (p<0.05).

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