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Platycodin D Impairs the Oncogenic Phenotypes of Esophageal Squamous Cell Carcinoma Cells by Elevating microRNA-4319

Author(s): Shuo Zhang, Yinghua Ma and Xiao Geng*
Department of Oncology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, 1Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong 250002, China

Correspondence Address:
Xiao Geng, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong 250002, China, E-mail:

To probe the action of platycodin D in the oncogenic phenotypes of esophageal squamous cell carcinoma cells and its possible mechanism. Esophageal squamous cell carcinoma cell line EC9706 was exposed to different doses of platycodin D (2.5, 5 or 10 μmol/l). Untreated cells were adopted as control group. After indicated transfection, functional analyses were carried out. The proliferation, migration and invasion of EC9706 cells were dose-dependently decreased by platycodin D. Moreover, platycodin D treatment dose-dependently increased microRNA-4319 levels in cells. MicroRNA-4319 rise impaired EC9706 cell proliferation, invasiveness and migration. Besides that, the inhibition of microRNA-4319 abolished the action of platycodin D in EC9706 cells. Platycodin D could impair cell proliferation, migration and invasion abilities in esophageal squamous cell carcinoma through elevating microRNA-4319.

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