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Abstract

Poly (Lactic Acid) Microspheres Of Ketorolac Tromethmine For Parenteral Controlled Drug Delivery System

Author(s): Shyamala Bhaskaran, B. S Sanmathi

Ketorolac tromethamine loaded poly (lactic acid) microspheres with different polymer composition were prepared by phase separation co-acervation induced by non-solvent addition method. The morphology of microspheres was analysed by scanning electron microscopy. The particle size distribution, studied by optical mlcroscopy, showed that particles are of uniform size. In vitro drug release profiles of these microspheres were studied using pH 7.4 phosphate buffer. The release kinetics of ketorolac tromethamine from the microspheres was evaluated by fitting the release data to the zero order, first order, Higuchi and Korsemeyer-Peppas equations. All microspheres showed initial burst release, followed by fickian diffusion of drug through microspheres. The stability of the formulations was found to be two years.

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