Abstract

Differential scanning calorimetry (DSC) was employed as a tool to investigate the physico-chemical compatability between metoprolol tartrate and a number of commonly used excipients. Metoprolol was found to be compatable with microcrystalline cellulose (Avicel PH 101®), Eudragit® and colloidal silicon dioxide (Aerosil®). Although metoprolol showed interactions with stearic acid, magnesium stearate, lactose, sodium carboxymethyl starch/sodium starch glycollate (Primojel®), Indian CRP 234and starch, one cannot conclusively state that interaction incompatabilities will occur on storage at room temperature.