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Abstract
Preformulation studies of a prodrug of ciprofloxacin.
Author(s): AG Swaminathan, SP Agarwal
Dept. of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, New Delhi-110 062,
Correspondence Address:
A G Swaminathan Dept. of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, New Delhi-110 062
Dept. of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, New Delhi-110 062,
Correspondence Address:
A G Swaminathan Dept. of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, New Delhi-110 062
A prodrug of Ciprofloxacin was synthesized by reacting the free base with aqueous formaldehyde solution in a 1:1 mixture of methylene chloride and methanol. The colourless, crystalline Nhydroxymethyl derivative, m.p. 238-242 degree C showed enhanced solubility and a three fold increase in the dissolution rate over parent drug. The degradation kinetics, pH-rate profile and antimicrobial activity of the prodrug were also determined.
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