Preformulation studies of a prodrug of ciprofloxacin.
Dept. of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, New Delhi-110 062,
A G Swaminathan Dept. of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, New Delhi-110 062
A prodrug of Ciprofloxacin was synthesized by reacting the free base with aqueous formaldehyde solution in a 1:1 mixture of methylene chloride and methanol. The colourless, crystalline Nhydroxymethyl derivative, m.p. 238-242 degree C showed enhanced solubility and a three fold increase in the dissolution rate over parent drug. The degradation kinetics, pH-rate profile and antimicrobial activity of the prodrug were also determined.PDF