All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Preformulation studies of a prodrug of ciprofloxacin.

Author(s): AG Swaminathan, SP Agarwal
Dept. of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, New Delhi-110 062,

Correspondence Address:
A G Swaminathan Dept. of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, New Delhi-110 062

A prodrug of Ciprofloxacin was synthesized by reacting the free base with aqueous formaldehyde solution in a 1:1 mixture of methylene chloride and methanol. The colourless, crystalline Nhydroxymethyl derivative, m.p. 238-242 degree C showed enhanced solubility and a three fold increase in the dissolution rate over parent drug. The degradation kinetics, pH-rate profile and antimicrobial activity of the prodrug were also determined.

PDF

 
 
List of Supporting Conferences